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Pages New Dacian's Medicine Lymphadenopathy (Classical / Allopathic Medicine)

Lymphadenopathy - enlargement of one or more lymph nodes - may result from increased production of lymphocytes or reticuloendothelial cells or from infiltration of cells that aren't normally present. This sign may be generalized (involving three or more node groups) or localized. Generalized lymphadenopathy may be caused by an inflammatory process, such as bacterial or viral infection; connective tissue disease; endocrine disorder; or neoplasm. Localized lymphadenopathy usually results from infection or trauma affecting the drained area. (See Causes of localized lymphadenopathy.)

Normally, lymph nodes range from ¼″ to 1″ (0.5 to 2.5 cm) in diameter and are discrete, mobile, nontender and, except in children, nonpalpable. (However, palpable nodes may be normal in adults.) Nodes that exceed 11/8″ (3 cm) in diameter are cause for concern. They may be tender, and the skin overlying the lymph node may be erythematous, suggesting a draining lesion. Or they may be hard and fixed, tender or nontender, suggesting a malignant tumor. Assess the patient for unilateral versus bilateral areas of lymphadenopathy.

Causes of localized lymphadenopathy
Various disorders can cause localized lymphadenopathy, but this sign usually results from infection or trauma affecting the drained area. Here you'll find some common causes of lymphadenopathy listed according to the areas affected.

Auricular: Erysipelas; Herpes zoster ophthalmicus; Infection; Rubella; Squamous cell carcinoma; Styes or chalazion; Tularemia

Axillary: Breast cancer; Lymphoma; Mastitis

Cervical: Cat-scratch fever; Facial or oral cancer; Infection; Mononucleosis; Mucocutaneous lymph node syndrome; Rubella; Rubeola; Thyrotoxicosis; Tonsillitis; Tuberculosis; Varicella

Inguinal and femoral: Carcinoma; Chancroid; Lymphogranuloma venereum; Syphilis

Occipital: Roseola; Scalp infection; Seborrheic dermatitis; Tick bite; Tinea capitis

Popliteal: Infection

Submaxillary and submental: Cystic fibrosis; Dental infection; Gingivitis; Glossitis

Supraclavicular: Neoplastic disease

HISTORY:
Ask the patient when he first noticed the swelling and if it's located on one side of his body or both.
Review the patient's medical history for recent infection and other health problems. If a biopsy has ever been performed on one of the patient's lymph nodes, check to see if it revealed previously diagnosed cancer. Also, ask the patient if there's a family history of cancer.

PHYSICAL ASSESSMENT:
Palpate the entire lymph node system to determine the extent of lymphadenopathy and to detect other areas of local enlargement. Use the pads of your index and middle fingers to move the skin over underlying tissues at the nodal area.
If you detect enlarged nodes, note their size in centimeters and whether they're fixed or mobile, tender or nontender, erythematous or nonerythematous, and tender or rough. Is the node discrete or does the area feel matted?
If you detect tender, erythematous lymph nodes, check the area drained by that part of the lymph system for signs of infection, such as erythema and swelling. Also, palpate for and percuss the spleen.

SPECIAL CONSIDERATIONS:
Expect to obtain blood for routine blood work, platelet count, and liver and renal function studies. If tests reveal infection, check your facility's policy regarding infection control.

PEDIATRIC POINTERS:
Infection is the most common cause of lymphadenopathy in children. The condition is commonly associated with otitis media and pharyngitis.

PATIENT COUNSELING:
Tell the patient that a fever under 101° F (38.3° C) may assist recovery and shouldn't be treated with an antipyretic, unless he's very uncomfortable. Advise him to try and soothe the fever with tepid baths.


Bibliography:

1. Rapid Assessment, A Flowchart Guide to Evaluating Signs & Symptoms, Lippincott Williams & Wilkins, 2004.
2. Professional Guide to Signs and symptoms, Edition V, Lippincott Williams & Wilkins, 2007.
3. Guide to common symptoms, Edition V, McGraw - Hill, 2002.

Dorin, Merticaru (2010)