STUDY - Technical - New Dacian's Medicine
Skin
Manifestations of Internal Diseases (7)
Translation Draft
Readers of this blog know that "register" positions on the blog type debt to realize the posts on which I self-obligated, following to resolve this duty when I have the time necessary (and that until August 15, by Saint Mary). So...
Since August 1st I have started a kind of total involvement in the launch of my project "Around the Worlds" about which I will give details as soon as I have a "consistent meal" to give you an idea of what I do (chit that does not directly interest readers " New Medicine" - but only indirectly by the lyrical-epic/ "Esop-ian" "extrapolation" of the "spirit" segment of the "body-mind-spirit" triad that I have mentioned in several previous posts). In addition it is necessary/ even desired by me, to get involved in a new collaborative project related to the site www.copilaziadultmaine.ro (in an IT participation with the soul of this site, Mădălina Artene), and in two older "debts" to which I have extended too much "delay" represented by the photo site of Viorel Neagu www.viorelneagu.ro and my old project about Romania (from the Section Romania from the www.dorinm.ro with the starting address http://dorinm.ro/study/romania/romania.html in direct relation to the launch of the site www.romaniatraditii.ro) Where else do you say that I want the complete change (interface, access mode, update, further development, etc.) of my old / old site www.dorinm.ro (which will pass "in a late" on the way of the rewarding operation, in the sense that it will be accessible "for money" - over time I came to a kind of conclusion like "with a kilo' of fame you can purchase a kil' hosting/ or potatoes?!?") ... my life, isn't it? Anyway, I will not let you down and I will do my best to go ahead with New Medicine in a regime of at least 3 posts per week (this project will span a "distance" of at least five years, according to my calculations, until it has some form - and that with the will of the Good Lord who must be by my side).
Thank you for your understanding and I hope to be as helpful as possible by what I do (for example, few of you know that, in the more than 14 years of diverse activity on the net reached thirty-five million hits through my various forms of activity without having to gain even a single lion / ROL or RON - only this blog has on this date over 4,500 hits, launched on January 1st this year, without taking into account the clone of facebook - and I do not keep this statistic but external "registration" engines, as in the case of the 35 million that I mentioned previously)!
From here on out will the "in a row" post about New Medicine... It's already 05.08.2014 and I hope that I will recover quickly... Get to work! We're going to continue with "yesterday"...
And we've reached the pink lesions... Skin lesions associated with primary systemic amyloidosis are pink, translucent. frequent localizations are the face, especially the periorbital and perioral regions, and the flexural areas. At biopsy, homogeneous deposits of amyloid are found in the dermis and walls of blood vessels, the latter leading to an increase in the fragility of the vascular wall. As a result, spots and purple appear in the clinically normal skin, as well as in the lesion, after minor trauma, hence the term "purple of pinching". Amyloid deposits are also found in the striated muscles of the tongue and lead to macroglossy.
Although specific mucocutaneous lesions are rare in secondary amyloidosis and are present only in about 30% of patients with primary amyloidosis, a rapid diagnosis of systemic amyloidosis can be made by examining abdominal subcutaneous fat. By special coloration, deposits are highlighted around blood vessels or individual fat cells in 40-50% of patients. There are also three forms of amyloidosis that are limited to the skin and should not be interpreted as skin lesions of systemic amyloidosis. They are macular amyloid (upper back), lichenoid amyloidosis (usually the lower limbs) and medullary amyloidosis. In macal and lichenoid amyloidosis, deposits are composed of modified epidermal keratin. Recently, macal and lichenoid amyloidosis has been associated with multiple endocrine neoplasia syndrome, type 2a.
Patients with multicentric reticulohistiocytosis also have pink nodules and papules on their face and mucous membranes, as well as in the extension areas of the hands and forearms. They have a arthritis that can clinically mimic rheumatoid arthritis. On histological examination, papules have characteristic giant cells, which are not found in biopsies of rheumatoid nodules. Papules ranging from pink to firm skin color, 2-5 mm in diameter and often in a linear arrangement are found in patients with papular mucinosis. This disease is also called lichen mixedematos or scleromixedema. This last name comes from the heightened induration of the face and extremities, which may accompany the papulous eruption. Biopsies in the papules show localized deposition of mucin and serum protein electrophoresis show a monoclonal peak of IgG, usually with a slightly "small lambda" chain.
It's yellow lesions. Many systemic conditions are characterized by yellow skin plaques or papules, such as hyperlipidemia (xantomas), gout (tofi), diabetes (lipoid necrobiosis), pseudoxantoma elasticum and Torre syndrome (sebaceous tumors). Eruptive xantomas are the most common forms of xantomas and are associated with hypertriglycerideemia (types 1,3 4 and 5). Bouquets of yellow papules with erythematous halos appear primarily on the extensor faces of the extremities and on the buttocks, in association with increases in circulating triglycerides. They spontaneously evolve at the same time as the decrease of serum lipids. Increased beta-lipoproteins (especially types 2 and 3) produce one or more of the following types of xantomas: xantelasma, xantomas of tendons and flat xantomas.
Xantelasma appears on the eyelids, while tendinous xantomas are commonly associated with Achilles tendons and finger extenders (flat xantomas are smooth and have predilection for palm grooves, face, upper torso and scar). Tuberous xantomas are commonly associated with hypertriglycerideemia, but are also found in patients with hypercholesterolemia (type 2) and are most commonly found in regions of large joints or in the hand. Biopsy of xantoms shows collections of macrophages containing lipids (foamy cells). Patients with several conditions, including bile cirrhosis, may have a secondary form of hyperlipidemia, with associated tuberous and flat xantomas.
However, myeloma patients have normolypemy plane xantomas. This latter form of xantomas is generally more than 12 cm in diameter and is most commonly found on the upper or laterocervical trunk. It is also important to note that the most important condition in which eruptive xantomas occur is uncontrolled diabetes mellitus. The least specific sign of hyperlipidemia is xantelasma, since at least 50% of patients with this sign have normal lipid profiles.
In gout tofacee there are skin deposits of ugly monosodic in periarticular areas, especially the joints of the hands and feet. Additional areas of tofi formation include ear helix, olecran and prepatelary bursaries. The lesions are firm, yellow in color and sometimes a creus material is discharged. Their dimensions range from 1 mm to 7 cm and the diagnosis can be established by polarizing the aspirated contents of a lesion. Injuries of lipoid necrobobiosis are mostly pretibial (90%) and most patients have diabetes or develop it later. Characteristic lesions have central yellow color, atrophy (transparency), telangiectasis and an erythematous edge.
Ulcerations can also occur inside the plates. Biopsy shows collagen necrobobiosis, granulomatous inflammation and obliterating endarteritis. In pseudoxantoma elasticum (PXE) there is an abnormal deposition of calcium on the elastic fibers of the skin, eye and blood vessels. Cutaneous, flexural areas such as the neck, armpits, antecubital fossa and groin are the first affected regions. Yellow papules fuse to form reticulated plaques with a similar appearance to "chicken skin". Severely damaged skin has excessive hanging folds. Some patients have a more subtle, subtle form of disease and careful inspection is required.
Biopsy of the affected skin shows swelled and irregularly grouped elastic fibers with calcium deposits. In the eyes, calcium deposits in the Bruch membrane lead to angioid bands and choroiditis (in the arteries of the heart, kidney, gastrointestinal tract and extremities, deposits lead to the appearance of angina, hypertension, gastrointestinal bleeding and claudication, respectively). Long-term administration of D-penicillin may cause skin disorders similar to those in PXE, as well as changes in elastic fibers in the internal organs.
Tumors of the appendages that have differentiated to the sebaceous glands include: sebaceous adenoma, sebaceous epithelioma, sebaceous carcinoma and sebaceous hyperplasia. Apart from sebaceous hyperplasia that is commonly found on the face, these tumors are solitary and unusual. Patients with Torre syndrome have sebaceous adenomas and in most cases there are multiple such tumors.
These patients may also have sebaceous carcinomas and sebaceous hyperplasia, as well as keratoacantomas. Internal manifestations of Torre syndrome include multiple carcinomas of the gastrointestinal tract (primarily the colon), as well as cancers of the larynx, genitourinary tract, ovary and endometrium. Some patients also have a family history of cancer.
No more of this post... In the next I'll approach red and "similar"...
Readers of this blog know that "register" positions on the blog type debt to realize the posts on which I self-obligated, following to resolve this duty when I have the time necessary (and that until August 15, by Saint Mary). So...
Since August 1st I have started a kind of total involvement in the launch of my project "Around the Worlds" about which I will give details as soon as I have a "consistent meal" to give you an idea of what I do (chit that does not directly interest readers " New Medicine" - but only indirectly by the lyrical-epic/ "Esop-ian" "extrapolation" of the "spirit" segment of the "body-mind-spirit" triad that I have mentioned in several previous posts). In addition it is necessary/ even desired by me, to get involved in a new collaborative project related to the site www.copilaziadultmaine.ro (in an IT participation with the soul of this site, Mădălina Artene), and in two older "debts" to which I have extended too much "delay" represented by the photo site of Viorel Neagu www.viorelneagu.ro and my old project about Romania (from the Section Romania from the www.dorinm.ro with the starting address http://dorinm.ro/study/romania/romania.html in direct relation to the launch of the site www.romaniatraditii.ro) Where else do you say that I want the complete change (interface, access mode, update, further development, etc.) of my old / old site www.dorinm.ro (which will pass "in a late" on the way of the rewarding operation, in the sense that it will be accessible "for money" - over time I came to a kind of conclusion like "with a kilo' of fame you can purchase a kil' hosting/ or potatoes?!?") ... my life, isn't it? Anyway, I will not let you down and I will do my best to go ahead with New Medicine in a regime of at least 3 posts per week (this project will span a "distance" of at least five years, according to my calculations, until it has some form - and that with the will of the Good Lord who must be by my side).
Thank you for your understanding and I hope to be as helpful as possible by what I do (for example, few of you know that, in the more than 14 years of diverse activity on the net reached thirty-five million hits through my various forms of activity without having to gain even a single lion / ROL or RON - only this blog has on this date over 4,500 hits, launched on January 1st this year, without taking into account the clone of facebook - and I do not keep this statistic but external "registration" engines, as in the case of the 35 million that I mentioned previously)!
From here on out will the "in a row" post about New Medicine... It's already 05.08.2014 and I hope that I will recover quickly... Get to work! We're going to continue with "yesterday"...
And we've reached the pink lesions... Skin lesions associated with primary systemic amyloidosis are pink, translucent. frequent localizations are the face, especially the periorbital and perioral regions, and the flexural areas. At biopsy, homogeneous deposits of amyloid are found in the dermis and walls of blood vessels, the latter leading to an increase in the fragility of the vascular wall. As a result, spots and purple appear in the clinically normal skin, as well as in the lesion, after minor trauma, hence the term "purple of pinching". Amyloid deposits are also found in the striated muscles of the tongue and lead to macroglossy.
Although specific mucocutaneous lesions are rare in secondary amyloidosis and are present only in about 30% of patients with primary amyloidosis, a rapid diagnosis of systemic amyloidosis can be made by examining abdominal subcutaneous fat. By special coloration, deposits are highlighted around blood vessels or individual fat cells in 40-50% of patients. There are also three forms of amyloidosis that are limited to the skin and should not be interpreted as skin lesions of systemic amyloidosis. They are macular amyloid (upper back), lichenoid amyloidosis (usually the lower limbs) and medullary amyloidosis. In macal and lichenoid amyloidosis, deposits are composed of modified epidermal keratin. Recently, macal and lichenoid amyloidosis has been associated with multiple endocrine neoplasia syndrome, type 2a.
Patients with multicentric reticulohistiocytosis also have pink nodules and papules on their face and mucous membranes, as well as in the extension areas of the hands and forearms. They have a arthritis that can clinically mimic rheumatoid arthritis. On histological examination, papules have characteristic giant cells, which are not found in biopsies of rheumatoid nodules. Papules ranging from pink to firm skin color, 2-5 mm in diameter and often in a linear arrangement are found in patients with papular mucinosis. This disease is also called lichen mixedematos or scleromixedema. This last name comes from the heightened induration of the face and extremities, which may accompany the papulous eruption. Biopsies in the papules show localized deposition of mucin and serum protein electrophoresis show a monoclonal peak of IgG, usually with a slightly "small lambda" chain.
It's yellow lesions. Many systemic conditions are characterized by yellow skin plaques or papules, such as hyperlipidemia (xantomas), gout (tofi), diabetes (lipoid necrobiosis), pseudoxantoma elasticum and Torre syndrome (sebaceous tumors). Eruptive xantomas are the most common forms of xantomas and are associated with hypertriglycerideemia (types 1,3 4 and 5). Bouquets of yellow papules with erythematous halos appear primarily on the extensor faces of the extremities and on the buttocks, in association with increases in circulating triglycerides. They spontaneously evolve at the same time as the decrease of serum lipids. Increased beta-lipoproteins (especially types 2 and 3) produce one or more of the following types of xantomas: xantelasma, xantomas of tendons and flat xantomas.
Xantelasma appears on the eyelids, while tendinous xantomas are commonly associated with Achilles tendons and finger extenders (flat xantomas are smooth and have predilection for palm grooves, face, upper torso and scar). Tuberous xantomas are commonly associated with hypertriglycerideemia, but are also found in patients with hypercholesterolemia (type 2) and are most commonly found in regions of large joints or in the hand. Biopsy of xantoms shows collections of macrophages containing lipids (foamy cells). Patients with several conditions, including bile cirrhosis, may have a secondary form of hyperlipidemia, with associated tuberous and flat xantomas.
However, myeloma patients have normolypemy plane xantomas. This latter form of xantomas is generally more than 12 cm in diameter and is most commonly found on the upper or laterocervical trunk. It is also important to note that the most important condition in which eruptive xantomas occur is uncontrolled diabetes mellitus. The least specific sign of hyperlipidemia is xantelasma, since at least 50% of patients with this sign have normal lipid profiles.
In gout tofacee there are skin deposits of ugly monosodic in periarticular areas, especially the joints of the hands and feet. Additional areas of tofi formation include ear helix, olecran and prepatelary bursaries. The lesions are firm, yellow in color and sometimes a creus material is discharged. Their dimensions range from 1 mm to 7 cm and the diagnosis can be established by polarizing the aspirated contents of a lesion. Injuries of lipoid necrobobiosis are mostly pretibial (90%) and most patients have diabetes or develop it later. Characteristic lesions have central yellow color, atrophy (transparency), telangiectasis and an erythematous edge.
Ulcerations can also occur inside the plates. Biopsy shows collagen necrobobiosis, granulomatous inflammation and obliterating endarteritis. In pseudoxantoma elasticum (PXE) there is an abnormal deposition of calcium on the elastic fibers of the skin, eye and blood vessels. Cutaneous, flexural areas such as the neck, armpits, antecubital fossa and groin are the first affected regions. Yellow papules fuse to form reticulated plaques with a similar appearance to "chicken skin". Severely damaged skin has excessive hanging folds. Some patients have a more subtle, subtle form of disease and careful inspection is required.
Biopsy of the affected skin shows swelled and irregularly grouped elastic fibers with calcium deposits. In the eyes, calcium deposits in the Bruch membrane lead to angioid bands and choroiditis (in the arteries of the heart, kidney, gastrointestinal tract and extremities, deposits lead to the appearance of angina, hypertension, gastrointestinal bleeding and claudication, respectively). Long-term administration of D-penicillin may cause skin disorders similar to those in PXE, as well as changes in elastic fibers in the internal organs.
Tumors of the appendages that have differentiated to the sebaceous glands include: sebaceous adenoma, sebaceous epithelioma, sebaceous carcinoma and sebaceous hyperplasia. Apart from sebaceous hyperplasia that is commonly found on the face, these tumors are solitary and unusual. Patients with Torre syndrome have sebaceous adenomas and in most cases there are multiple such tumors.
These patients may also have sebaceous carcinomas and sebaceous hyperplasia, as well as keratoacantomas. Internal manifestations of Torre syndrome include multiple carcinomas of the gastrointestinal tract (primarily the colon), as well as cancers of the larynx, genitourinary tract, ovary and endometrium. Some patients also have a family history of cancer.
No more of this post... In the next I'll approach red and "similar"...
Have a good day!
Dorin, Merticaru